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    首頁>>免疫學(xué)>>一抗>>細(xì)胞色素C單克隆抗體  
    

    

    
	
    
    	
    
        	
    細(xì)胞色素C單克隆抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN42011M
      
                        
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      中文名稱：
      
                            
      細(xì)胞色素C單克隆抗體 
      
                        
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      英文名稱：
      
                            
      Mouse anti-Cytochrome C Monoclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
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      BN42011M-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Rat,Mouse,Human   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF
      
                            
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      BN42011M-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Rat,Mouse,Human   推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱Cytochrome C
    中文名稱細(xì)胞色素C單克隆抗體
    別    名CytC; CYC; CYCS; Cytochrome c somatic; HCS; CYC_HUMAN; Cytochrome c; MSA06; THC4.

    研究領(lǐng)域腫瘤  心血管  細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞凋亡  線粒體  
    抗體來源Mouse
    克隆類型Monoclonal
    克 隆 號(hào)6B10
    交叉反應(yīng)Human, Rat,  (predicted: Mouse, )
    產(chǎn)品應(yīng)用WB=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量14kDa
    細(xì)胞定位細(xì)胞漿 線粒體
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原Recombinant human Cytochrome C Protein: 
    亞    型IgG
    純化方法affinity purified by Protein G
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome C has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome C is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.

    Function:
    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

    Subcellular Location:
    Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.

    Post-translational modifications:
    Binds 1 heme group per subunit.
    Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.

    DISEASE:
    Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.

    Similarity:
    Belongs to the cytochrome c family.

    SWISS:
    P99999

    Gene ID:
    54205

    Database links:
    Entrez Gene: 54205 Human
    Entrez Gene: 13063 Mouse
    Entrez Gene: 25309 Rat
    Omim: 123970 Human
    SwissProt: P99999 Human
    SwissProt: P62897 Mouse
    SwissProt: P62898 Rat
    Unigene: 437060 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    細(xì)胞色素C（cytC）是一種電子傳遞鏈蛋白為線粒體呼吸鏈必須的成份之一。在哺乳動(dòng)物細(xì)胞中，如此高度保守性蛋白常分布在線粒體內(nèi)膜。
    新近研究證明細(xì)胞漿中細(xì)胞色素C為激活細(xì)胞調(diào)亡所必需的因子。在調(diào)亡的過程中，細(xì)胞色素C從線粒體膜被易位到細(xì)胞漿，由細(xì)胞色素C激活Caspase-3（CPP32）。
    細(xì)胞色素C的易位可被過量表達(dá)的Bcl-2阻斷。細(xì)胞色素B與細(xì)胞色素C1和Rieske蛋白相結(jié)合而形成復(fù)合物III（也稱細(xì)胞色素B-C1復(fù)合物）參與細(xì)胞呼吸鏈。該蛋白動(dòng)物種屬間同源性較高；如 ：豬、犬、牛、雞、豚鼠等。