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    首頁>>免疫學>>一抗>>生長分化因子15/巨嗜細胞抑制因子1抗體  
    

    

    
	
    
    	
    
        	
    生長分化因子15/巨嗜細胞抑制因子1抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41878R
      
                        
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      中文名稱：
      
                            
      生長分化因子15/巨嗜細胞抑制因子1抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-GDF15 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      產品規格
      
                                
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      BN41878R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應：Human,Mouse,Rat   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41878R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse,Rat   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41878R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應：Human,Mouse,Rat   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱GDF15
    中文名稱生長分化因子15/巨嗜細胞抑制因子1抗體
    別    名GDF 15; GDF-15; GDF15_HUMAN; Growth differentiation factor 15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC 1; Mic-1; MIC1; NAG 1; NAG-1; NAG1; NRG 1; NRG-1; NRG1; NSAID (nonsteroidal anti inflammatory drug) activated protein 1; NSAID; NSAID regulated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; Placental bone morphogenic protein; Placental TGF beta; Placental TGF-beta; Prostate differentiation factor; PTGF beta; PTGFB.   



    研究領域心血管  細胞生物  信號轉導  細胞周期蛋白  細胞分化  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat, 
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量12.5/34kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human GDF-15:221-308/308 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.

    Subcellular Location:
    Secreted.

    Tissue Specificity:
    Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.

    Similarity:
    Belongs to the TGF-beta family.

    SWISS:
    Q99988

    Gene ID:
    9518

    Database links:
    Entrez Gene: 9518 Human
    Entrez Gene: 23886 Mouse
    Entrez Gene: 29455 Rat
    Omim: 605312 Human
    SwissProt: Q99988 Human
    SwissProt: Q9Z0J7 Mouse
    SwissProt: Q9Z0J6 Rat
    Unigene: 616962 Human
    Unigene: 31325 Mouse
    Unigene: 44228 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    生長分化因子15（GDF15）是骨形態發生蛋白（BMP）和轉化生長因子-β超家族成員。GDF-15又叫巨噬細胞抑制因子（macrophage inhibiting cytokine，MIC）-1、胎盤轉化生長因子 （placental transformation growth factor，PTGF）-β、前列腺衍生因子（prostate derived factor，PDF）和胎盤骨形態發生蛋白（placental bone morphogeneticprotein，PLAB）。
    有學者認為：GDF-15在腫瘤發展的不同階段發揮著不同的生物學作用；隨著腫瘤的發生發展，GDF-15可能表達不同形式的蛋白，在腫瘤發生的早期階段可能發揮抑瘤作用，而在腫瘤發展的后期階段發揮促瘤作用。