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產(chǎn)品規(guī)格
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BN41859R-50ul
50ul
￥1486.00
交叉反應：Human 推薦應用：WB,IHC-P,ELISA
BN41859R-100ul
100ul
￥2360.00
交叉反應：Human 推薦應用：WB,IHC-P,ELISA
產(chǎn)品描述
| 英文名稱 | AIF1/Iba1 |
| 中文名稱 | 離子鈣接頭蛋白抗體 |
| 別 名 | AIF 1; AIF1; AIF1 protein; IBa1; iba-1; IBa 1; allograft inflammatory factor 1; Allograft inflammatory factor 1 splice variant G; balloon angioplasty responsive transcription; BART 1; G1; G1 putative splice variant of allograft inflamatory factor 1; IBA 1; IBA1; interferon gamma responsive transcript; Ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule; IRT 1; IRT1; Microglia response factor; MRF1; Protein G1. |
| 研究領域 | 細胞生物 免疫學 神經(jīng)生物學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:50-100 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 16.7kDa |
| 細胞定位 | 細胞漿 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AIF1:6-36/147 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M PBS(pH7.4) with 0.03% Proclin300. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Allograft Inflammatory Factor-1 (AIF1)or ionized calcium-binding adaptor molecule 1 (Iba1) is expressed selectively in microglia/macrophages and is a Ca2+-binding peptide produced by activated monocytes and microglial cells. It has been suggested that AIF1 expression is associated with chronic inflammatory processes. AIF1 is expressed by activated monocytes and might participate in a variety of pathogenic processes in the mammalian brain and in chronic transplant rejection. It has been shown to be expressed early and persistently in chronically rejecting cardiac allografts but not in cardiac syngrafts and host hearts. Function: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. Subunit: Homodimer (Potential). Monomer. Interacts with LCP1. Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. Tissue Specificity: Detected in T-lymphocytes and peripheral blood mononuclear cells. Similarity: Contains 2 EF-hand domains. SWISS: P55008 Gene ID: 199 Database links: Entrez Gene: 199 Human Entrez Gene: 11629 Mouse Omim: 601833 Human SwissProt: P55008 Human SwissProt: O70200 Mouse Unigene: 76364 Human Unigene: 10747 Mouse Unigene: 32080 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 離子鈣接頭蛋白主要在小膠質(zhì)細胞表達. |
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