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產品規格
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BN41658R-50ul
50ul
￥1486.00
交叉反應：Human,Mouse,Rat(predicted:Chicken) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41658R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse,Rat(predicted:Chicken) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41658R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse,Rat(predicted:Chicken) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
產品描述
| 英文名稱 | SOX4 |
| 中文名稱 | 核轉錄因子SOX4抗體 |
| 別 名 | SOX4; SOX 4; SOX-4; Ecotropic viral integration site 16; EVI 16; EVI16; SRY (sex determining region Y) box 4; SRY box containing gene 4; SRY related HMG box gene 4; SOX4_HUMAN. |
| 研究領域 | 神經生物學 干細胞 轉錄調節因子 表觀遺傳學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, (predicted: Chicken, ) |
| 產品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SOX4:54-103/474 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Function: The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate. SOX4 shows a high degree of sequence homology with SOX11. Both are expressed in the CNS. SOX4 and SOX11 expression increase together in the developing CNS (with some exceptions: external granule layer of the cerebellum). SOX4 knock-out mice have been shown to die of a heart defect half way through gestation with no observable CNS phenotype, although it has been proposed that SOX11 compensates for the absence of SOX4. Subunit: Interacts with UBE2I. Subcellular Location: Nuclear Tissue Specificity: Testis, brain, and heart. Similarity: Contains 1 HMG box DNA-binding domain. SWISS: Q06945 Gene ID: 6659 Database links: Entrez Gene: 395143 Chicken Entrez Gene: 6659 Human Entrez Gene: 20677 Mouse Entrez Gene: 336346 Zebrafish Omim: 184430 Human SwissProt: Q06945 Human SwissProt: Q06831 Mouse Unigene: 643910 Human Unigene: 240627 Mouse Unigene: 455819 Mouse Unigene: 163667 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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