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產品規格
售價
備注
BN41576R-50ul
50ul
￥1486.00
交叉反應：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41576R-100ul
100ul
￥2360.00
交叉反應：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41576R-200ul
200ul
￥3490.00
交叉反應：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
產品描述
| 英文名稱 | IL-10 |
| 中文名稱 | 白細胞介素10抗體 |
| 別 名 | Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. |
| 研究領域 | 細胞生物 免疫學 轉錄調節因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, (predicted: Rat, Chicken, Pig, Rabbit, Sheep, Guinea Pig, ) |
| 產品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 18kDa |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-10:101-178/178 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. Similarity: Belongs to the IL-10 family. SWISS: P18893 Gene ID: 3586 Database links: Entrez Gene: 3586 Human Entrez Gene: 16153 Mouse Omim: 124092 Human SwissProt: P22301 Human SwissProt: P18893 Mouse Unigene: 193717 Human Unigene: 874 Mouse Unigene: 9868 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 白細胞介素-10(IL-10)是主要由Th2細胞所產生的一種細胞因子，活化的B細胞、單核巨噬細胞和枯否氏細胞（Kupffer's cell）等也可產生IL-10。它是以抑制Th細胞克隆細胞因子合成為特點的多效免疫調節因子。 白介素-10是維護細胞因子網絡平衡的重要負調節因子。其作用機制可能是降低抗原遞呈細胞MHCⅡ類抗原表達，或誘導抗原遞呈細胞產生另一種細胞因子，改變細胞內信號傳遞途徑，從而選擇性抑制某些細胞因子mRNA轉錄，并與Th2細胞產生的IL-4、IL-5有協同作用。 |
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