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    首頁>>免疫學(xué)>>一抗>>黑色素瘤相關(guān)抗原/黑色素-A抗體  
    

    

    
	
    
    	
    
        	
    黑色素瘤相關(guān)抗原/黑色素-A抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號：
      
                            
      BN41473R
      
                        
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      中文名稱：
      
                            
      黑色素瘤相關(guān)抗原/黑色素-A抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Melan A Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號
      
                                
      產(chǎn)品規(guī)格
      
                                
      售價
      
                                
      備注
      
                            
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      BN41473R-50ul
      
                                
      50ul
      
                                
      ￥1486.00
      
                                
      交叉反應(yīng)：Human   推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41473R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human   推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
      
                            
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      BN41473R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human   推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱Melan A
    中文名稱黑色素瘤相關(guān)抗原/黑色素-A抗體
    別    名Protein Melan-A; Antigen LB39 AA; MelanA; Melanoma HMB45; Antigen SK29 AA; Antigen SK29-AA; CMM 1; CMM; CMM1; Cutaneous Malignant Melanoma Dysplastic Nevus; DNS; Dysplastic Nevus Syndrome; FAMMM; MART1; melan A; Melan A protein; Melanoma antigen recognized by T-cells 1; MLM; Monophenol monooxygenase; Tumor rejection antigen AB; tyrosinase; Melanoma HMB45; Melanoma; Melan-A; MART-1; MAR1_HUMAN.  
    研究領(lǐng)域腫瘤  細胞生物  免疫學(xué)  腫瘤細胞生物標志物  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, 
    產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量13kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Melan-A:51-118/118 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Melan A, a product of the MART-1 gene, is a melanocyte differentiation marker recognized by autologous cytotoxic T lymphocytes. Other melanoma-associated markers recognized by autologous cytotoxic T cells are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1. The analysis of these different molecules and their expression in individual melanomas may be of help in the study of their particular molecular roles in melanocyte differentiation and tumorigenesis.

    Function:
    Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

    Subunit:
    Interacts with PMEL. Interacts with GPR143.

    Subcellular Location:
    Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

    Tissue Specificity:
    Expression is restricted to melanoma and melanocyte cell lines and retina.

    Post-translational modifications:
    Acylated.

    SWISS:
    Q16655

    Gene ID:
    2315

    Database links:
    Entrez Gene: 2315 Human
    Omim: 605513 Human
    SwissProt: Q16655 Human
    Unigene: 154069 Human


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    信號中間體（Signaling Intermediates）
    MelanA/MART-1是分化腫瘤抗原類別中具有代表性的成員，它表達于正常的黑素細胞和大多數(shù)原發(fā)及轉(zhuǎn)移的黑色素瘤中，故稱：黑色素瘤相關(guān)抗原。
















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