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產(chǎn)品規(guī)格
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BN41401R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應用：WB,ELISA
BN41401R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應用：WB,ELISA
產(chǎn)品描述
| 英文名稱 | NHEDC2 |
| 中文名稱 | 線粒體鈉/氫交換蛋白質(zhì)2抗體 |
| 別 名 | NHA2; Mitochondrial Na(+)/H(+) exchanger NHA2; Mitochondrial sodium/hydrogen exchanger NHA2; Na(+)/H(+) exchanger like domain containing protein 2; Na+/H+ exchanger domain containing 2; NHE domain containing protein 2; NHE10; NHEDC 2; Sodium/hydrogen exchanger like domain containing protein 2; SL9B2_HUMAN. |
| 研究領域 | 細胞生物 信號轉(zhuǎn)導 細胞周期蛋白 細胞分化 細胞骨架 細胞外基質(zhì) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, (predicted: Rat, Dog, Rabbit, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 細胞定位 | 細胞漿 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NHEDC2:151-250/537 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Na+/H+ exchangers (NHEs) catalyze the transport of Na+ in exchange for H+ across membranes in organisms and are required for numerous physiological processes. NHEDC2 (Na+/H+ exchanger-like domain-containing protein 2), also known as NHA2, is a 537 amino acid mitochondrial protein. NHEDC2 is involved in organelle volume homeostasis by catalyzing the exchange of protons for Na+ and Li+ across the inner mitochondrial membrane. Found in red blood cells, NHEDC2 is required for bone resorption activity and osteoclast differentiation. As a multi-pass membrane protein, NHEDC2 is expressed as two isoforms produced by alternative splicing events. Function: Electroneutral exchange of protons for Na(+) and Li(+)across the inner mitochondrial membrane. Contributes to theorganellar volume homeostasis. Required for osteoclastdifferentiation and bone resorption activity (By similarity). Subcellular Location: Mitochondrion membrane; Multi-pass membraneprotein (By similarity). Tissue Specificity: Detected in red blood cells (at proteinlevel). Similarity: Belongs to the monovalent cation:proton antiporter 1(CPA1) transporter (TC 2.A.36) family. SWISS: Q86UD5 Gene ID: 133308 Database links: Entrez Gene: 133308 Human Entrez Gene: 97086 Mouse Omim: 611789 Human SwissProt: Q86UD5 Human SwissProt: Q5BKR2 Mouse Unigene: 546482 Human Unigene: 441764 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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