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    首頁>>免疫學>>一抗>>富含亮氨酸重復蛋白SHOC2抗體  
    

    

    
	
    
    	
    
        	
    富含亮氨酸重復蛋白SHOC2抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產品貨號：
      
                            
      BN41289R
      
                        
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      中文名稱：
      
                            
      富含亮氨酸重復蛋白SHOC2抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-SHOC2 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      產品規格
      
                                
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      BN41289R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Sheep)   推薦應用：WB,IHC-P,IHC-F,IF,ELISA
      
                            
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    產品描述
    
                
    
                
    
                	
    英文名稱SHOC2
    中文名稱富含亮氨酸重復蛋白SHOC2抗體
    別    名Leucine-rich repeat protein SHOC-2; Leucine-rich repeat protein SHOC-2; Ras-binding protein Sur-8; KIAA0862; Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; Protein Sur-8 homolog; SHOC2; SHOC2_HUMAN.  
    研究領域細胞生物  信號轉導  細胞周期蛋白  激酶和磷酸酶  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量65kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human SHOC2/Sur8:36-120/582 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
    Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.

    Function:
    Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

    Subunit:
    Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBB2IP; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS.

    Subcellular Location:
    Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation.

    DISEASE:
    Defects in SHOC2 are the cause of Noonan syndrome-like disorder with loose anagen hair (NSLH) [MIM:607721]. A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair.

    Similarity:
    Belongs to the SHOC2 family.
    Contains 20 LRR (leucine-rich) repeats.

    SWISS:
    Q9UQ13

    Gene ID:
    8036

    Database links:
    Entrez Gene: 8036 Human
    Entrez Gene: 56392 Mouse
    Entrez Gene: 309548 Rat
    Omim: 602775 Human
    SwissProt: Q9UQ13 Human
    SwissProt: O88520 Mouse
    SwissProt: Q6AYI5 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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