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    首頁(yè)>>免疫學(xué)>>一抗>>凋亡相關(guān)蛋白4抗體  
    

    

    
	
    
    	
    
        	
    凋亡相關(guān)蛋白4抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN41126R
      
                        
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      中文名稱：
      
                            
      凋亡相關(guān)蛋白4抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-PDCD4 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN41126R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human(predicted:Mouse)   推薦應(yīng)用：WB,IHC-P
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱PDCD4
    中文名稱凋亡相關(guān)蛋白4抗體
    別    名PDCD-4; PDCD 4; Death up-regulated gene protein; Dug; H731; Ma3; MGC33046; MGC33047; Neoplastic transformation inhibitor; Neoplastic transformation inhibitor protein; Nuclear antigen H731; Nuclear antigen H731 like; Nuclear antigen H731 like protein; PDCD 4; Programmed cell death 4; programmed cell death 4 (neoplastic transformation inhibitor); Programmed cell death protein 4; Protein 197/15a; Protein MA-3; RP11 348N5.4; Tis; Nuclear antigen H731-like; Pdcd4; PDCD4_HUMAN; Topoisomerase-inhibitor suppressed protein; Topoisomerase-inhibitor suppressed protein (programmed cell death 4).  
    研究領(lǐng)域腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  表觀遺傳學(xué)  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human,  (predicted: Mouse, )
    產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:400-800 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量51kDa
    細(xì)胞定位細(xì)胞核 細(xì)胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原Recombinant human PDCD4:1-260/469 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified. Alternative names: H731; MGC33046; MGC33047; Neoplastic transformation inhibitor; Neoplastic transformation inhibitor protein; Nuclear antigen H731; Nuclear antigen H731 like; Nuclear antigen H731 like protein; OTTHUMP00000020483; PDCD 4; Programmed cell death 4; programmed cell death 4 (neoplastic transformation inhibitor) ; Programmed cell death protein 4; Protein 197/15a ; RP11 348N5.4 .

    Function:
    Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

    Subunit:
    Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.

    Subcellular Location:
    Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.

    Tissue Specificity:
    Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.

    Post-translational modifications:
    Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
    Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.

    Similarity:
    Belongs to the PDCD4 family.
    Contains 2 MI domains.

    SWISS:
    Q53EL6

    Gene ID:
    27250

    Database links:
    Entrez Gene: 27250 Human
    Entrez Gene: 18569 Mouse
    Entrez Gene: 64031 Rat
    Omim: 608610 Human
    SwissProt: Q53EL6 Human
    SwissProt: Q61823 Mouse
    SwissProt: Q9JID1 Rat
    Unigene: 711490 Human
    Unigene: 1605 Mouse
    Unigene: 375091 Mouse
    Unigene: 206228 Rat


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    程序性細(xì)胞死亡因子4是近期發(fā)現(xiàn)一種新的抑癌基因，在很多腫瘤組織中有不同的表達(dá)。