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    首頁(yè)>>免疫學(xué)>>一抗>>腺苷酸環(huán)化酶1抗體  
    

    

    
	
    
    	
    
        	
    腺苷酸環(huán)化酶1抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN40943R
      
                        
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      中文名稱：
      
                            
      腺苷酸環(huán)化酶1抗體 
      
                        
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      英文名稱：
      
                            
      Rabbit anti-Adenylate cyclase 1 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN40943R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human,Rat(predicted:Mouse)   推薦應(yīng)用：WB,IHC-P,ELISA
      
                            
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      BN40943R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human,Rat(predicted:Mouse)   推薦應(yīng)用：WB,IHC-P,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱Adenylate cyclase 1
    中文名稱腺苷酸環(huán)化酶1抗體
    別    名3'5' cyclic AMP synthetase; ADCY1; adenyl cyclase; adenylate cyclase type I; ATP pyrophosphate lyase; Brain adenylate cyclase 1; Ca(2+)/calmodulin activated adenylyl cyclase; EC 4.6.1.1; ADCY1_HUMAN; Adenylate cyclase type 1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase. .  
    研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Rat,  (predicted: Mouse, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （石蠟切片需做抗原修復(fù)）
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量123kDa
    細(xì)胞定位細(xì)胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human adenylate cyclase type I:751-850/1119 <Cytoplasmic>
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹The membrane bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein coupled receptors. Eight human AC isoforms (AC-1 through AC-4) have been identified up to now and genes for at least nine adenylate cyclase (AC-1-AC-9) have been cloned characterized and sequenced. This is a calmodulin-sensitive adenylyl cyclase which may be involved in regulatory processes in the central nervous system. It may play a role in neuronal plasticity, memory acquisition and learning and is expressed predominantly in the brain, retina and adrenal medulla.

    Function:
    This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.

    Subcellular Location:
    Membrane; Multi-pass membrane protein.

    Tissue Specificity:
    Brain, retina and adrenal medulla.

    Similarity:
    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
    Contains 2 guanylate cyclase domains.

    SWISS:
    Q08828

    Gene ID:
    107

    Database links:
    Entrez Gene: 107 Human
    Entrez Gene: 432530 Mouse
    Omim: 103072 Human
    SwissProt: Q08828 Human
    SwissProt: O88444 Mouse
    Unigene: 192215 Human
    Unigene: 259733 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    腺苷酸環(huán)化酶(adenylate cyclase, AC) 是G蛋白偶聯(lián)受體家族之一，是膜整合蛋白,它的氨基端和羧基端都朝向細(xì)胞質(zhì)。AC在膜的細(xì)胞質(zhì)面有兩個(gè)催化結(jié)構(gòu)域,還有兩個(gè)膜整合區(qū),每個(gè)膜整合區(qū)分別有6個(gè)跨膜的α螺旋。哺乳動(dòng)物中已發(fā)現(xiàn)6個(gè)腺苷酸環(huán)化酶異構(gòu)體。由于AC能夠?qū)TP轉(zhuǎn)變成cAMP,引起細(xì)胞的信號(hào)應(yīng)答,因此,腺苷酸環(huán)化酶是G蛋白偶聯(lián)系統(tǒng)中的效應(yīng)