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    首頁(yè)>>免疫學(xué)>>一抗>>叉頭蛋白P3抗體  
    

    

    
	
    
    	
    
        	
    叉頭蛋白P3抗體
     
    
            
    
            	
    
            	
    
                	
      
                    	
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      產(chǎn)品貨號(hào)：
      
                            
      BN40751R
      
                        
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      中文名稱(chēng)：
      
                            
      叉頭蛋白P3抗體 
      
                        
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      英文名稱(chēng)：
      
                            
      Rabbit anti-FoxP3 Polyclonal antibody 
      
                        
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      品牌：
      
                            
      Biorigin 
      
                        
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      貨號(hào)
      
                                
      產(chǎn)品規(guī)格
      
                                
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      備注
      
                            
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      BN40751R-100ul
      
                                
      100ul
      
                                
      ￥2360.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep)   推薦應(yīng)用：WB,ICC,Flow-Cyt,ELISA
      
                            
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      BN40751R-200ul
      
                                
      200ul
      
                                
      ￥3490.00
      
                                
      交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep)   推薦應(yīng)用：WB,ICC,Flow-Cyt,ELISA
      
                            
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    產(chǎn)品描述
    
                
    
                
    
                	
    英文名稱(chēng)FoxP3
    中文名稱(chēng)叉頭蛋白P3抗體
    別    名AIID; AIID; DIETER; DIETER; Forkhead box P3; Forkhead box protein P3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocrinopathy enteropathy X linked; IPEX; IPEX; JM2; JM2; MGC141961; MGC141963; OTTHUMP00000025832; OTTHUMP00000025833; OTTHUMP00000226737; PIDX; PIDX; SCURFIN; SCURFIN; XPID; XPID.  
    研究領(lǐng)域細(xì)胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  淋巴細(xì)胞  
    抗體來(lái)源Rabbit
    克隆類(lèi)型Polyclonal
    交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Sheep, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量47kDa
    細(xì)胞定位細(xì)胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human FoxP3:351-431/431 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

    Function:
    Probable transcription factor. Plays a critical role in the control of immune response.

    Subunit:
    Interacts with IKZF3.

    Subcellular Location:
    Nucleus (Potential).

    Post-translational modifications:
    Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1.

    DISEASE:
    Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.

    Similarity:
    Contains 1 C2H2-type zinc finger.
    Contains 1 fork-head DNA-binding domain.

    SWISS:
    Q9BZS1

    Gene ID:
    50943

    Database links:
    Entrez Gene: 50943 Human
    Entrez Gene: 20371 Mouse
    Entrez Gene: 317382 Rat
    Omim: 300292 Human
    SwissProt: Q9BZS1 Human
    SwissProt: Q99JB6 Mouse
    SwissProt: D3ZKI1 Rat
    Unigene: 247700 Human
    Unigene: 182291 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    叉頭蛋白3(FOXP3)是FOX蛋白家族成員之一,主要為T(mén)細(xì)胞轉(zhuǎn)錄蛋白，主要表達(dá)于T細(xì)胞+CD4+CD25,并調(diào)節(jié)該類(lèi)T細(xì)胞的發(fā)育和功能.
    FOXP3的表達(dá)受轉(zhuǎn)化生長(zhǎng)因子-β雌激素和糖皮質(zhì)激素等調(diào)節(jié),通過(guò)競(jìng)爭(zhēng)性抑制活化T細(xì)胞核因子的轉(zhuǎn)錄活性而發(fā)揮作用.自身免疫性糖尿病患者體內(nèi)CD4+CD25+T細(xì)胞減少,誘導(dǎo)FOXP3的表達(dá)或過(guò)繼轉(zhuǎn)移CD4+CD25+T細(xì)胞有可能預(yù)防自身免疫性糖尿病
















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